Role of neutrophil-lymphocyte ratio in predicting mortality in acute coronary syndrome patients

Abstract Funding Acknowledgements Type of funding sources: None. Background Inflammation is the basic mechanism acute coronary syndrome (ACS). Among various inflammatory markers related to ACS neutrophil-lymphocyte ratio (NLR). Neutrophils act as a mediator response damage myocardium, while lymphocytes decrease because apoptosis caused by inflammation. Therefore, high NLR suggests further risk infarction myocardium. Purpose This study determines cut-off value and role at admission in predicting in-hospital mortality patients. Methods A retrospective cohort was conducted using data patients admitted with from SCIENCE registry between February 2019 November 2020. The inclusion criterion complete blood count measurement presentation. calculated absolute neutrophil lymphocyte count. optimal determined receiver operating characteristic (ROC) curve Youden index (J) analysis. Patients divided into two groups based on value. In-hospital compared Chi-square test estimate obtain relative risk. Results total 1147 aged 60,70 ± 10,951 years old were included study. Area under ROC 0,607 (95% CI: 0,559-0,655; p <0,001). cutoff predict 10,7566 (sensitivity: 39,8%, specificity: 79,5%, J: 0,193). occurred 64 266 (24,1%) >10,7566 97 881 (11%) <10,7566, 2,185 1,645-2,904; Conclusion In >10,7566, there an increased times higher <10,7566. can be used Mortality incidence groupsNLR >10.7566 (n= 266)NLR <10.7566 881)P-valueRelative risk95% CIMortality64 (24.1%)97 (11%)<0.0012.1851.645-2.904Non-mortality202 (75.9%)784 (89%)NLR ratio, confidence interval, P-value considered significant if <0.005Abstract Figure.